WebDec 8, 2024 · Kontny and Mulski showed that the brittleness of both empty gelatin capsules and formulation-filled capsules becomes prevalent at RH values of less … WebCapsule brittleness Tested by different robustness evaluation methods, Quali-V ® Extra Dry capsules, with an extremely low moisture content (2.0-3.5%), demonstrate that they maintain their physical stability and do not become brittle when exposed to ambient conditions with low humidity.
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Web-possible causes: aggregation of powder/ granule fill, changes in drug physical properties, property changes in capsule shell-testing parameters: >hard gelatine capsules: brittleness, dissolution, dissolution, disintegration, water content, microbial contamination WebJun 28, 2024 · Stability studies should include testing of those attributes of the active substance that aresusceptible to change during storage and are likely to influence quality, safety, and/or efficacy.The testing should cover, as appropriate, the physical, chemical, biological, andmicrobiological attributes. Webbrittleness, and dissolution performance of the shell. Capsules can also be characterized by the chemical properties of the fill material (hydrophobic-based versus … how to make your own whatsapp stickers