WebEs war einer der aufsehenerregendsten Arzneimittel-Skandale in Deutschland. Das millionenfach eingenommene Schlafmittel Contergan galt als ungefährlich - doc... WebJun 17, 2016 · In the 1950s, thalidomide (Contergan) was prescribed as a sedative drug to pregnant women, resulting in a great number of infants with serious malformations. Up to now, the reasons for these ...
Contergan Scandal – DW – 01/07/2008
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Contergan Article about Contergan by The Free Dictionary
Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. While thalidomide has been used in a … See more Thalidomide is used as a first-line treatment for multiple myeloma in combination with dexamethasone or with melphalan and prednisone to treat acute episodes of erythema nodosum leprosum, as well as for … See more Thalidomide should not be used by men or women who are trying to father or conceive a child, those who cannot or will not follow the risk … See more The precise mechanism of action for thalidomide is not known, although efforts to identify thalidomide's teratogenic action generated 2,000 research papers and the proposal of 15 or … See more In 1952, thalidomide was synthesised by Chemical Industry Basel (CIBA), but was found "to have no effect on animals" and was discarded on … See more Thalidomide causes birth defects. The U.S. Food and Drug Administration (FDA) and other regulatory agencies have approved marketing of the drug only with an auditable See more Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the See more Birth defect crisis In the late 1950s and early 1960s, more than 10,000 children in 46 countries were born with deformities, such as phocomelia, as a consequence … See more WebThe Contergan dose was 200 mg daily and the dexamethasone dose was 40 mg orally once daily on days 1-4, 9-12, and 17-20 every 28-days. Each group was treated for four 28-day cycles. Study 2 randomized 470 newly diagnosed patients with MM to Contergan plus dexamethasone (N=235) versus placebo plus dexamethasone (N=235). WebJun 3, 2024 · Behind closed doors: The Contergan scandal. Until the 60s, the sleep-inducing drug was mass produced and distributed worldwide. But, after ingesting the … drug screen randomizer program