Web5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the basis of its ability to bind to highly divergent 50–60 bp sequences within the promoter region of the chicken Myc gene ... WebMar 23, 2024 · The mammalian CTCF is the best characterized genome architectural protein that binds to insulator elements [ 2, 8 ]. CTCF directionally and dynamically binds to tens of thousands of CTCF-binding sites (CBS elements) in mammalian genomes through the combinatorial usage of its 11 zinc fingers [ 9, 10 ].
The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting ...
WebNov 1, 2014 · Furthermore, a single-nucleotide polymorphism (SNP) in the 5′ region of the H19 gene and located near CTCF-binding sites has been associated with abnormal birth … WebJun 28, 2024 · CTCF is a multivalent 11-zinc finger DNA-binding protein that is ubiquitously expressed in most tissues of vertebrate species ( 1–4 ). Combinatorial usage of CTCF zinc fingers ( 4, 5) allows its binding to tens of thousands of conserved DNA sites as revealed by chromatin immunoprecipitation sequencing (ChIP-seq) experiments ( 6–8 ). college of iowa savings
CTCF - an overview ScienceDirect Topics
WebWe first categorized CTCF-dependent reduced chromatin contacts based on the presence of CBSs on anchor sites. The majority of CTCF-dependent E–P and P–P contacts were anchored by CBSs at... WebAug 1, 2010 · In this study we investigated the feasibility of a novel anti-cancer adenovirus (AdDC312-DT-A) driven by H19 enhancer DMD-H19 promoter complex. Cell lines with IGF2 LOI (HCT-8, HT-29 and H-522) that were infected … WebSymbol: CTCF-DT: Name: CTCF divergent transcript: RGD ID: 16562422: HGNC Page: HGNC:55409: Description: Type: ncrna (Ensembl: lncRNA) RefSeq Status: college of islamic studies hbku