Mannitol use with cisplatin
Web30. avg 2024. · Purpose Acute kidney injury (AKI) is a frequent dose-limiting toxicity induced by cisplatin. Mannitol has been used in hydration protocols to mitigate this adverse … http://elephantcare.org/resources/formulary/drug-index/mannitol/
Mannitol use with cisplatin
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WebIt is concluded that renal toxicity is less severe in patients treated with cisplatin, hydration, and mannitol and that the use of cisPlatin alone or in combination with other active agent(s) should be considered for further evaluation in previously untreated patients with malignant melanoma. In a prospective phase II randomized trial, a dose of 100 mg/m2 iv … Web01. maj 2024. · Mannitol is an osmotic diuretic that is indicated for the promotion of diuresis; it is a logical choice for reduction of cisplatin-induced nephrotoxicity as it is nontoxic and …
WebOur study emphasized the common clinical practice using mannitol with hydration to reduce cisplatin nephrotoxicity. This study was prematurely stopped because of slow … Web28. jul 2024. · Some studies suggest the use of mannitol or furosemide as an osmotic diuretic to prevent renal toxicity, but results are inconsistent and furosemide may itself be ototoxic (Crona et al., ... Historically investigated as a potential nephroprotective agent for use with cisplatin (Baldwin et al., 1994; Somlo et al., 1995), ...
WebIt is concluded that renal toxicity is less severe in patients treated with cisplatin, hydration, and mannitol and that the use of cisPlatin alone or in combination with other active … Web05. feb 2014. · Cisplatin (≥60 mg/m 2) was administered over 60 min on Day 1 in combination with other chemotherapeutic agents, mannitol and 2500 ml of hydration. In the Mg preloading group, patients received a solution consisting of 500 ml of isotonic saline plus 8 mEq of magnesium sulfate before the administration of cisplatin over 60 min.
Web25. sep 2024. · 242 Background: Cisplatin is a widely used chemotherapeutic in treating malignancies. A common side effects of cisplatin is kidney injury, or nephrotoxicity. This …
Web12. apr 2024. · Our data suggests that the addition of mannitol to saline hydration did not aid in decreasing the risk of cisplatin-induced AKI compared when compared to … example of nationality in malaysiaWeb31. jan 2012. · Mannitol plus hydration has been used for several years to alleviate toxicity associated with cisplatin therapy. However, the data for mannitol administration have not been convincing. When the use of mannitol and hydration is compared directly to hydration alone, mannitol shows no benefit. brunswick gold crown pool table 1960sWeb01. jan 2016. · In conventional treatment regimens employing doses of cisplatin of less than 100 mg/m(2) in patients with normal renal function, pre- and post-hydration (3 l/m(2) at … example of national marketsWebObjective: To review the efficacy and safety of concomitant mannitol administration with cisplatin therapy to reduce the incidence of nephrotoxicity. Data sources: A literature … example of national taxWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … example of narrative observation early yearsWeb05. feb 2024. · Patients were randomly assigned to either a mannitol 20 g intravenous single dose after cisplatin or a placebo (saline). The primary outcome was to compare … example of nationality in south africaWeb01. feb 2012. · To review the efficacy and safety of concomitant mannitol administration with cisplatin therapy to reduce the incidence of nephrotoxicity. A literature search was … example of nationalism today