Phenytoin hypothermia
Web7. sep 2024 · Hypothermia is a rare, but potentially fatal adverse effect of antipsychotic drug (APD) use. ... Possible long-acting risperidone-induced hypothermia precipitating phenytoin toxicity in an elderly patient. J Clin Pharm Ther (2011) 36:426–42. 10.1111/j.1365-2710.2010.01189.x ... WebPhenytoin toxicity continues to be a common medical problem. It can present with subtle and atypical symptoms. Herein the authors report what is, to their knowledge, the first case in the literature of phenytoin toxicity that manifested solely in the form of hypothermia.
Phenytoin hypothermia
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Web22. jan 2024 · Routine work-up revealed toxic levels of phenytoin. No cause of hypothermia could be identified but as his phenytoin levels normalised, his body temperature also improved. There are three... Web1. dec 2006 · The cardiac depressant actions of phenytoin and hypothermia can be additive. Administration of phenytoin in the presence of hypothermia may lead to an adverse cardiac event in children. As...
WebTherapeutic hypothermia is induced by reducing core body temperature via a wide array of surface cooling and intravenous cooling methods. Randomized control trials demonstrating neuroprotection have employed therapeutic hypothermia at 32–34°C for 12–24 hours in adults and up to 48–72 hours for pediatric patients. WebThis unintentional significant drop in core body temperature may have resulted in altered metabolism of phenytoin leading to supratherapeutic concentrations and subsequent tonic-clonic seizures, bradycardia and neutropenia. Low core body temperatures can alter the pharmacokinetic profiles of hepatic …
WebNo cause of hypothermia could be identified but as his phenytoin levels normalised, his body temperature also improved. There are three other reported cases of phenytoin- induced hypothermia in the literature. Web1. nov 2006 · Volume 13, Issue 9, November 2006, Pages 953-955. Case report. Is phenytoin administration safe in a hypothermic child?
WebTrial-drug vials contained levetiracetam (50 mg per milliliter), fosphenytoin (16.66 mg phenytoin equivalents [mgPE] per milliliter), or valproate (33.33 mg per milliliter).
Web1. nov 2006 · We emphasize that the cardiac depressant actions of phenytoin and hypothermia may be synergistic. Phenytoin is a commonly used drug in neuroanaesthesia, neurology and neurosurgical practice. Its administration in hypothermic children may have far-reaching cardiac consequences and prevention of hypothermia would be the most … include a picture with an emailWeb17. okt 2006 · Full text; References Citations & impact Similar Articles Is phenytoin administration safe in a hypothermic child? inc holiday topsWebThe authors examined the effect of mild therapeutic hypothermia on phenytoin pharmacokinetics in 14 patients with brain damage. Each patient was given phenytoin during and after mild therapeutic hypothermia. Plasma concentrations of total phenytoin, unbound phenytoin, and 5-(p-hydroxyphenyl)-5-pheny … include a range of teaching strategiesWebRandomized control trials demonstrating neuroprotection have employed therapeutic hypothermia at 32–34°C for 12–24 hours in adults and up to 48–72 hours for pediatric patients. Clinical implementation of therapeutic hypothermia can be divided into induction, maintenance and rewarming phases. include a python file in anotherWeb1. okt 2013 · MEASUREMENTS AND MAIN RESULTS: A sum of 121 total and 114 free phenytoin levels were evaluated retrospectively in 10 hypothermia-treated and nine normothermia-treated children who were... inc holidayWeb14. jan 2024 · Phenytoin TDM is therefore clinically important in the critically ill and should be followed closely. At normal serum levels, patients may experience minor central nervous system depression and adverse effects such as nystagmus, drowsiness, or fatigue. … include a referenceWeb1. jan 2024 · No cause of hypothermia could be identified but as his phenytoin levels normalised, his body temperature also improved. There are three other reported cases of phenytoin- induced hypothermia in the literature. Could this be a rare cause of hypothermia? http://dx.doi.org/10.1136/bcr-2024-227443 Request Permissions inc house sxsw