WebSummary Brand Names Name Accession Number Background Type Groups Structure Weight Chemical Formula Synonyms External IDs Pharmacology Indication Associated … WebPhenobarbitone may harm your baby if taken during pregnancy. Abnormalities include heart disease, problems with the structure of the mouth (cleft palate) and face, spina-bifida, and …

Efficacy and Safety of Phenobarbitone as First-Line Treatment for ...

WebPhenobarbital is used to control seizures. Phenobarbital is also used to relieve anxiety. It is also used to prevent withdrawal symptoms in people who are dependent ('addicted'; feel a need to continue taking the medication) on another barbiturate medication and are going to stop taking the medication. Phenobarbital is in a class of medications ... Phenobarbital is metabolized by the liver, mainly through hydroxylation and glucuronidation, and induces many isozymes of the cytochrome P450 system. Cytochrome P450 2B6 ( CYP2B6) is specifically induced by phenobarbital via the CAR / RXR nuclear receptor heterodimer. It is excreted primarily by the … See more Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) … See more Phenobarbital is used in the treatment of all types of seizures, except absence seizures. It is no less effective at seizure control than See more Acute intermittent porphyria, hypersensitivity to any barbiturate, prior dependence on barbiturates, severe respiratory insufficiency See more Phenobarbital is as an allosteric modulator which extends the amount of time the chloride ion channel is open by interacting with GABAA receptor subunits. Through this action, phenobarbital increases the flow of chloride ions into the neuron which decreases the … See more Sedation and hypnosis are the principal side effects (occasionally, they are also the intended effects) of phenobarbital. Central nervous system effects, such as dizziness, nystagmus and ataxia, are also common. In elderly patients, it may cause excitement and … See more Phenobarbital causes a depression of the body's systems, mainly the central and peripheral nervous systems. Thus, the main characteristic of phenobarbital overdose is a "slowing" of bodily functions, including decreased consciousness (even coma See more Phenobarbital has an oral bioavailability of about 90%. Peak plasma concentrations (Cmax) are reached eight to 12 hours after oral administration. … See more job window washer

Phenobarbital Oral Solution: Package Insert - Drugs.com

Webspectra of phenobarbitone in the region 4000–400cm–1, and Raman spectra in the region 3500–50cm–1. But so far no theoretical work is done on vibrational spectra of … WebPhenobarbitalincreases the seizure threshold and reduces the spread of discharge from an epileptic focus. Pharmacokinetics Phenobarbitalis completely absorbed after oral … WebDec 3, 2012 · Phenobarbital’s pKa (−log of the dissociation constant − Ka) is similar to that of the physiologic blood pH, and therefore phenobarbital is 50% ionized and 50% … job windows server