Tead1 motif
Webb1 okt. 2024 · The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological functions. WebbIntroduction. Chronic rhinosinusitis (CRS), with an estimated prevalence of 8% in China, 1 is defined as chronic inflammation of the nose and the paranasal sinuses. CRS with nasal polyps has been typically characterised by epithelial remodelling, manifested as abnormal epithelial proliferation, basal cell proliferation, a thickened sub-epithelial basement …
Tead1 motif
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http://genesdev.cshlp.org/content/24/3/235.full.html WebbHowever, the luciferase activity of TEAD1 motif mutant pgl3-Mfn2 vector increased, indicating that TEAD1 would inhibit the transcription of Mfn2 (Figure S9A, right panel). Based on the luciferase experiments and TEAD1 motif peak enrichment, Dnm1l and Mfn1 were revealed to be regulated by TEAD1 complex in same manner, while Mfn2 was …
WebbTEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)) is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway … WebbInvolved in cardiac development. Binds to the M-CAT motif. Tissue specificity. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. Involvement in disease. ... TEAD1. Mass Spectrometry - Recombinant Human TEF1/TEAD-1 protein (His tag) (ab226236)
WebbTEAD1 binds the low-affinity inverted M-CAT motif in 180° rotated orientation • Helices facing the other side from DNA are stabilized upon … Webb21 aug. 2015 · The TEAD consensus motif is enriched in YAP1 binding sites YAP1 does not contain a DNA-binding domain and thus, relies on interactions with other TFs for …
Webb15 dec. 2008 · Although Tead1 proteins constantly localized to the nuclei, the level of nuclear Tead1 was reduced at a high cell density(Fig. 1C,D,F). To monitor the transcriptional activity of endogenous Tead proteins, we exploited a Tead reporter (8×GT-IIC-Luc) containing an 8-mer of a Tead-binding motif,GT-IIC ( Davidson et al., 1988 )( Fig. …
Webb15 juni 2024 · For instance, TEAD1 variants may be a rare cause of Aicardi syndrome, a congenital disorder characterised by agenesis of the corpus callosum, neuronal … csapp ripWebbThe conserved TEAD1 binding motif was depicted with red letters, and the TLR4 coding sequences were indicated with green letters. (B). TEAD1 ChIP qPCR. A primer set spanning the mouse Tlr4... marcelle tendrihWebb1 okt. 2024 · TEAD1 overexpression restores AQP4 expression, and both TEAD1 and AQP4 overexpression rescue migratory deficits in TEAD1-knockout cells, implicating a direct … marcelle tagandWebb31 aug. 2024 · YAP and TAZ have a TEAD domain that interacts with TEAD1-4, and they contain WW domains ... For motif occurrence analysis, TEAD, JUNB, STAT3, CEBPA, and NF-κb motifs were downloaded from the HOCOMOCO and JASPAR databases (Kulakovskiy et al., 2024; Fornes et al., 2024). marcelle tauber-gilmoreWebbMolecular docking and smFRET revealed that TEAD1 binds the inverted motif rotated 180°. In addition, the inverted motif was proven to be occupied by TEAD1 in Jurkat cells, … c sapporo vs vissel kobe predictionWebb8 dec. 2024 · The PDZ-binding motif of YAP is critical for YAP-mediated oncogenesis, and that this effect is mediated by YAP's co-activation of TEAD-mediated CTGF transcription. TEAD1 regulates C2C12 differentiation through negatively regulating the expression of Ccne1, which can explain the transition between proliferation and differentiation. marcelle tatum chattanooga tnWebb24 juni 2015 · promoter. MCF10A cells starved in serum-free medium for 18 h were stimulated with 5% horse serum for 2 h. The cells were then subjected to chromatin immunoprecipitation (ChIP) with antibodies to endogenous YAP or TEAD1 (or control IgG), and the precipitated DNA was quantitated by real-time PCR analysis with primers … csapp sicp